ABSTRACT
OBJECTIVE@#To explore the clinical manifestations, diagnosis, treatment and prognosis of blastic plasmacytoid dendritic cell neoplasm(BPDCN).@*METHODS@#The clinical features, bone marrow morphology and immunophenotyping, treatment and prognosis of 4 patients with BPDCN were analyzed retrospectively.@*RESULTS@#4 patients had bone marrow， spleen and lymph nodes involvement， 2 patients had skin lesions， and 3 patients had central nervous system infiltration． Tailing phenomenon of abnormally cells could be seen in bone marrow. The immunophenotyping showed that CD56, CD4 and CD123 expression was observed in 4 patients， and CD304 in 3 patients． One patient refused chemotherapy and died early. Both patients achieved complete remission after the initial treatment with DA+VP regimen, 1 of them achieved complete remission after recurrence by using the same regimen again． One patient failed to respond to reduced dose of DA+VP chemotherapy, and then achieved complete remission with venetoclax+azacitidine.@*CONCLUSION@#The malignant cells in BPDCN patients often infiltrate bone marrow, spleen and lymph nodes, and have specical phenotypes, with poor prognosis. The treatment should take into account both myeloid and lymphatic systems. The treatment containing new drugs such as BCL-2 inhibitors combined with demethylation drugs is worth trying.
Subject(s)
Humans , Dendritic Cells , Retrospective Studies , Skin Neoplasms/pathology , Antineoplastic Agents/therapeutic use , Bone Marrow/pathology , Myeloproliferative Disorders , Hematologic Neoplasms/drug therapyABSTRACT
Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate (4-OI) is a cell-permeable itaconate derivative and has been recognized as a promising therapeutic target for the treatment of inflammatory diseases. Here, we explored, for the first time, the protective effect of 4-OI on inhibiting periodontal destruction, ameliorating local inflammation, and the underlying mechanism in periodontitis. Here we showed that 4-OI treatment ameliorates inflammation induced by lipopolysaccharide in the periodontal microenvironment. 4-OI can also significantly alleviate inflammation and alveolar bone loss via Nrf2 activation as observed on samples from experimental periodontitis in the C57BL/6 mice. This was further confirmed as silencing Nrf2 blocked the antioxidant effect of 4-OI by downregulating the expression of downstream antioxidant enzymes. Additionally, molecular docking simulation indicated the possible mechanism under Nrf2 activation. Also, in Nrf2-/- mice, 4-OI treatment did not protect against alveolar bone dysfunction due to induced periodontitis, which underlined the importance of the Nrf2 in 4-OI mediated periodontitis treatment. Our results indicated that 4-OI attenuates inflammation and oxidative stress via disassociation of KEAP1-Nrf2 and activation of Nrf2 signaling cascade. Taken together, local administration of 4-OI offers clinical potential to inhibit periodontal destruction, ameliorate local inflammation for more predictable periodontitis.
Subject(s)
Animals , Mice , Alveolar Bone Loss/prevention & control , Antioxidants/pharmacology , Inflammation , Kelch-Like ECH-Associated Protein 1/metabolism , Mice, Inbred C57BL , Molecular Docking Simulation , NF-E2-Related Factor 2/metabolism , Periodontitis/prevention & control , SuccinatesABSTRACT
This study aimed to establish three-dimensional finite element models of micro-implants-lingual straight wire appliance and to investigate the effects of different wire patterns on the initial displacement of the maxillary anterior teeth and the stress of the periodontal ligament and tooth root during retracting maxillary anterior teeth in lingual orthodontics. A three-dimensional geometric models of maxilla with maxillary dentition was established using Cone-beam CT scan .Three types of maxilla models including microimplants and Duet-Slot Lingual Bracket appliance with three different arch wires ( model A: 0.016 inch × 0.022 inch stainless steel square wire; modelB: 0.016 inch stainless steel round wire; model C: double wire of 0.016 inch × 0.022 inch stainless steel square wire + anterior teeth 0.016 inch stainless steel round wire) were assembled by Unigraphics NX 8.5 software. The labial intrusion force and lingual retraction force were simulatively loaded to obtain initial displacement of the anterior teeth and the stresses of each tooth root and periodontal ligament, using three-dimensional finite element calculation software Ansys Workbench 15. The initial displacement of the lateral incisors was close to the bodily movement; and central incisors and lateral incisors slightly extruded. Compared with group A and group C, canine teeth appeared obviously horizontal "arched effect" by crown labial tipping in group B. The stress distribution of the tooth root and periodontal ligament was minimal and uniform in the group C. The 0.016 × 0.022- in stainless steel rectangular wire combined with 0.016- in stainless steel round wire used in the anterior teeth can better control the torque of the maxillary anterior teeth for space close in lingual orthodontics. Moreover, the stress distribution of tooth root and periodontal ligament is even, which is difficult to damage the periodontal ligament or result in external resorption of tooth root.
Este estudio tuvo como objetivo establecer modelos tridimensionales de elementos finitos de microimplantes linguales de alambre recto e investigar los efectos de diferentes patrones de alambre en el desplazamiento inicial de los dientes maxilares anteriores y el estrés del ligamento periodontal y la raíz del diente durante la retracción lingual sobre los dientes anteriores del hueso maxilar en ortodoncia. Se establecieron modelos geométricos tridimensionales del hueso maxilar con dentición utilizando una exploración por tomografía computarizada de haz cónico. Tres tipos de modelos maxilares, incluidos los microimplantes y el dispositivo Duet-Slot Lingual Bracket con tres arcos diferentes (modelo A: 0.016 pulgada × 0.022 pulgada alambre cuadrado de acero inoxidable; modelo B: alambre redondo de acero inoxidable de 0.016 pulgadas; alambre cuadrado de acero inoxidable de 0.016 pulgada × 0.022 pulgada y alambre redondo de acero inoxidable de 0.016 pulgada) ensamblados por el software Unigraphics NX 8.5. La fuerza de intrusión labial y la fuerza de retracción lingual se cargó simultáneamente, para obtener el desplazamiento inicial de los dientes anteriores y las tensiones de cada raíz dental y ligamento periodontal, usando el software tridimensional de cálculo de elementos finitos Ansys Workbench 15. El desplazamiento inicial de los incisivos laterales se relacionaba al movimiento corporal; mientra que los incisivos centrales e incisivos laterales se mostraron ligeramente extruidos. Comparado con el grupo A y el grupo C, los dientes caninos presentaron un "efecto arqueado" horizontal por la inclinación labial de la corona en el grupo B. La distribución del estrés de la raíz del diente y el ligamento periodontal fue mínima y uniforme en el grupo C. El alambre rectangular de acero inoxidable combinado con el alambre redondo de acero inoxidable de 0.016 usado en los dientes anteriores puede controlar mejor el torque de los dientes maxilares anteriores para cerrar el espacio en ortodoncia lingual. Además, la distribución del estrés de la raíz del diente y del ligamento periodontal es pareja, lo que dificulta dañar el ligamento periodontal o provocar una resorción externa de la raíz del diente.
Subject(s)
Humans , Orthodontic Wires , Prostheses and Implants , Tooth Movement Techniques , Orthodontic Brackets , Finite Element Analysis , Stainless Steel , Stress, Mechanical , Tongue , Biomechanical Phenomena , Materials Testing , MaxillaABSTRACT
SUMMARY: By analysing cephalometrics before and after the treatment of Angle's class II division 1 malocclusion, soft tissue profile changes were observed, and to explore whether there was a correlation between the change of posterior occlusal plane (OP-P) and soft tissue profile. The study aimed to provide a theoretical reference in the clinical diagnosis and orthodontic treatment of early permanent dentition of Angle class II division 1 malocclusion patients. We randomly selected 20 cases of orthodontics in Shanxi Medical University orthodontics patients (aged 12-18 years) of the lateral cephalograms, Winceph 8.0 software was used to measure the posterior occlusal plane (OP-P), TUL-EP, TLL-EP, nasolabial angle, upper lip base thickness, upper lip tension, lower lip H line distance, chin soft tissue thickness and Z angle. And SPSS 22.0 software was used to analyze the correlation between OP-P and other measurement indexes. The change of posterior occlusal plane was positively related to the distance from upper lip to the esthetic plane, the distance from lower lip to the esthetic plane, the tension of the upper lip and distance from lower lip to H line, and the change of posterior occlusal plane was negatively related to nasolabial angle and Z angle. The change of posterior occlusal plane had no significant correlation with upper lip base thickness and soft tissue chin thickness. The change of posterior occlusal plane has an important guiding significance for orthodontic treatment,by focusing on the change of the posterior occlusal plane to achieve the purpose of changing the soft tissue profile.
RESUMEN: Se realizó un estudio cefalométrico antes y después del tratamiento de ortodoncia en pacientes portadores de maloclusión clase II división 1 de Angle. Se observaron cambios en el perfil de los tejidos blandos y se exploró si había una correlación entre el cambio del plano oclusal posterior (OP-P) y el perfil de los tejidos blandos. El objetivo de este estudio fue otorgar una referencia teórica en el diagnóstico clínico y el tratamiento de ortodoncia de los pacientes con dentición permanente temprana con maloclusión clase II división 1 de Angle. Seleccionamos al azar 20 casos cefalometrías de pacientes de ortodoncia de la Universidad Médica de Shanxi (entre 12 y18 años). Para ello, se utilizó el software Winceph 8.0 para medir el plano oclusal posterior (OP-P), TUL-EP, TLL-EP, ángulo nasolabial, grosor de la base del labio superior, tensión del labio superior, distancia entre líneas del labio inferior H, grosor del tejido blando del mentón y ángulo Z. Se utilizó el software SPSS 22.0 para analizar la correlación entre OP-P y otros índices. El cambio del plano oclusal posterior tuvo una correlación positiva con la distancia desde el labio superior al plano estético, la distancia desde el labio inferior hasta el plano estético, la tensión del labio superior y distancia del labio inferior a la línea H. El cambio del plano oclusal posterior tuvo una correlación negativa con el ángulo nasolabial y el ángulo Z. El cambio del plano oclusal posterior no tuvo una correlación significativa con el grosor de la base del labio superior y la barbilla de tejido blando. El cambio del plano oclusal posterior tiene un importante significado de orientación para el tratamiento de ortodoncia, de tal manera que al cambiar el plano oclusal posterior se podrá lograr el propósito de cambiar el perfil del tejido blando.
Subject(s)
Humans , Adolescent , Young Adult , Cephalometry , Chin/anatomy & histology , Dental Occlusion , Lip/anatomy & histology , Malocclusion, Angle Class II/therapy , Orthodontics , Treatment Outcome , Malocclusion, Angle Class II/pathologyABSTRACT
SUMMARY: The objective of this study was to compare the Primary and Secondary stability of immediate implant placement with Alveolar Ridge Augmentation (ARA) and Strontium Ranelate (SR) as aids to enhance the stability using Resonance Frequency Analysis (RFA). Fifty eight subjects ideal for immediate implants were assigned to two groups to compare the primary and secondary stability of the implant using Alveolar Ridge Augmentation and oral strontium ranelate. They were tested for primary stability on placement of the implant and after eight weeks of placement for secondary stability. The stability was measured using resonance frequency analysis. Both the procedures showed an improvement in the stability but the Alveolar Ridge Augmentation procedure showed a significantly better primary stability (P< .03) and the secondary stability (P<.00). The means of the implant stability quotient value (ISQ) for the Alveolar ridge augmentation procedure was 74.2 for primary stability, and 83.34 for secondary stability. With the enhancement of stability with both the procedures Alveolar Ridge Augmentation proved to be a better procedure to achieve successful results of an immediately placed implant.
RESUMEN: El objetivo de este estudio fue comparar la estabilidad primaria y secundaria de la colocación inmediata del implante con el aumento de reborde alveolar (ARA) y el ranelato de estroncio (SR) como ayudas para mejorar la estabilidad mediante el análisis de frecuencia de resonancia (RFA). Cincuenta y ocho sujetos, ideales para implantes inmediatos, fueron asignados a dos grupos para comparar las estabilidades primaria y secundaria del implante usando el aumento del reborde alveolar y el ranelato de estroncio oral. Se efectuaron pruebas de estabilidad primaria en la colocación del implante, y después de ocho semanas para la estabilidad secundaria. La estabilidad se midió utilizando análisis de frecuencia de resonancia. Ambos procedimientos mostraron una mejora en la estabilidad, sin embargo el procedimiento del aumento del reborde alveolar mostró una estabilidad primaria significativamente mejor (P <0,03) que la estabilidad secundaria (P <0,00). Las medias del valor de cociente de estabilidad del implante (ISQ) para el procedimiento de aumento de reborde alveolar fueron 74,2 para la estabilidad primaria y 83,34 para la estabilidad secundaria. Se observó una mejora de la estabilidad en ambos procedimientos, el aumento del reborde alveolar demostró ser un mejor procedimiento para lograr resultados exitosos del posicionamiento de implante inmediato.
Subject(s)
Thiophenes/pharmacology , Dental Implants , Dental Prosthesis Retention , Alveolar Ridge Augmentation/methods , OsseointegrationABSTRACT
To investigate the effects of morphological characteristics of cranial base on malocclusion by analyzing characteristics of sagittal and vertical facial types of Angle's class II division 1 malocclusion so as to provide theoretical references for clinical diagnosis and correction of early Angle's class II division 1 malocclusion in permanent teeth. We randomly selected lateral radiographs of the skull of 80 patients at the age of 1214 years old from the Department of Orthodontics, Stomatological Hospital, Shanxi Medical University, China. There were 20 cases of Angle's class I malocclusion with average angle, 20 cases of Angle's class II division 1 malocclusion with average angle, 20 cases of Angle's class II division 1 malocclusion with low angle, and 20 cases of Angle's class II division 1 malocclusion with high angle. Winceph 8.0 software was used to measure 39 hard tissue markers and 13 indicators reflecting the characteristics of cranial base structure. One-way t-test was used in the average-angle class II division 1 group and average-angle class I group. Least significantdifference was utilized in patients with different vertical types of class II division 1 malocclusion.nterior (S-N) and posterior (S-Ba) cranial base lengths,and total cranial base length(Ba-N) were significantly longer in the class II division 1 patients compared with the class I patients. Significant differences in anterior cranial floor base angle (CF-PM), middle cranial floor base angle (Ba-SE-PM), and posterior cranial base inclination (SBa-FH) were determined between class II division 1 malocclusion and class I malocclusion patients. CF-PM angle and SBa-FH were smaller in class II division 1 subjects than in class I subjects. Ba-SE-PM angle and cranial floor base angle (Ba-SE-FMS) were larger in class II division 1 subjects than in class I subjects. No significant difference in cranial base angle (N-S-Ba) and anterior cranial base inclination (SN-FH) was detected between class II division 1 subjects and class I subjects. Morphology of cranial base and cranial floor base has a significant effect on sagittal and vertical facial types of Angle's class II division 1 malocclusion. The changes in the length of the posterior skull base and the inclination of the anterior skull base are mainly presented in the sagittal direction. Angle of cranial base and cranial floor base plays a certain role in vertical facial type of Angle's class II division 1 malocclusion.
El objetivo de este trabajo consistió en investigar los efectos de las características morfológicas de la base craneal sobre la maloclusión, a través del análisis de los siferentes tipos faciales de maloclusión Clase II de Angle (sagital y vertical), para proporcionar referencias teóricas para el diagnóstico clínico y la corrección temprana de la maloclusión de clase II división 1 de Angle en dientes permanentes. Se seleccionaron al azar radiografías laterales de cráneo de 80 pacientes, entre 12-14 años de edad, del Departamento de Ortodoncia, Hospital de Estomatología, Universidad Médica de Shanxi, China. Hubo 20 casos de maloclusión clase I de Angle con ángulo promedio, 20 casos de maloclusión clase II de Angle con ángulo promedio, 20 casos de maloclusión Clase II de Angle con ángulo bajo y 20 casos de maloclusión clase 1 de Angle con ángulo alto. Se utilizó el software Winceph 8.0 para medir 39 marcadores de tejido duro y 13 indicadores que reflejan las características de la estructura de la base de cráneo. Se usó la prueba t de una vía en el grupo clase II de división 1 con ángulo promedio y el grupo clase I con ángulo promedio. Se detectaron diferencias mínimas significativas en pacientes con diferentes tipos verticales de maloclusión clase II división 1. Las longitudes de la base de cráneo posterior (SN) y posterior (S-Ba), y la longitud total de la base craneal (Ba-N) fueron significativamente mayores en la clase II, en comparación con los pacientes de la clase I. Se determinaron diferencias significativas en el ángulo de la base del piso craneal anterior (CF-PM), el ángulo de la base del piso craneal medio (Ba-SE-PM) y la inclinación de la base craneana posterior (SBa-FH) entre la maloclusión clase II división 1 y los pacientes con maloclusión de clase I. Los ángulos de CF-PM y SBa-FH fueron más pequeños en la clase II división 1 que en la clase I. El ángulo de Ba-SE-PM y el ángulo de base del piso craneal (Ba-SE-FMS) fueron mayores en sujetos de clase II división 1 que en sujetos de clase I. No se detectaron diferencias significativas en el ángulo de la base craneana (N-S-Ba) y la inclinación de la base craneal anterior (SN-FH) entre los sujetos de la clase II división 1 y los de la clase I. La morfología de la base craneal y de la base del suelo craneal tiene un efecto significativo en los tipos faciales sagital y vertical de maloclusión Clase II división 1 de Angle. Los cambios en la longitud de la base posterior del cráneo y la inclinación de la base anterior del cráneo se presentaron principalmente en la dirección sagital. El ángulo de la base craneal y la base del suelo craneal tiene cierto rol en el tipo facial vertical de la clase II de Angle.
Subject(s)
Humans , Male , Female , Child , Adolescent , Cephalometry , Skull Base/pathology , Dentition, Permanent , Malocclusion, Angle Class II/pathologyABSTRACT
The current proxy indicators and quantitative strategy were summarized for cognitive reserve,the findings of cognitive reserve was discussed then in brain aging and Alzheimer's disease,and some future research directions were presented about cognitive reserve.The reserve of brain explains the disjunction between clinical symptoms and the degree of brain damage,whereby some people can tolerate more of age-related or Alzheimer's disease pathology than others and maintain brain function.The cognitive reserve hypothesis has been widely used in epidemiological and neuroimaging studies,but it lacks a unified quantitative indicator.The future research of cognitive reserve should be focused on the development of quantitative indicators that cover a variety of potential factors dynamically.
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Objective To explore the effect of enriched environmental stimulation on mouse brain cognitive reserve to enhance the sensitivity of brain age gap estimation (BrainAGE).Methods Twenty-one healthy adult C57BL / 6J male mice,15 months old,were divided into a group with a standard environment and two groups with enriched environments.All the groups underwent magnetic resonance microcopy.Scaled subprofile model was used to analyze the features reflecting the changes of brain cognitive reserve.Results There were significant differences between the mean BrainAGE of the two groups with enriched environments and that of the remained standard environment group,then it's proved that some assumption might be reasonable that brain cognitive reserve could be estimated based on BrainAGE.Optim ized BrainAGE model made explanations for 58.9％ differences during stimulus phase in enriched environment.Conclusion Improved BrainAGE model gains high sensitivity when used to measure the redundancy of brain cognitive reserve.
ABSTRACT
The current proxy indicators and quantitative strategy were summarized for cognitive reserve,the findings of cognitive reserve was discussed then in brain aging and Alzheimer's disease,and some future research directions were presented about cognitive reserve.The reserve of brain explains the disjunction between clinical symptoms and the degree of brain damage,whereby some people can tolerate more of age-related or Alzheimer's disease pathology than others and maintain brain function.The cognitive reserve hypothesis has been widely used in epidemiological and neuroimaging studies,but it lacks a unified quantitative indicator.The future research of cognitive reserve should be focused on the development of quantitative indicators that cover a variety of potential factors dynamically.
ABSTRACT
Objective To explore the effect of enriched environmental stimulation on mouse brain cognitive reserve to enhance the sensitivity of brain age gap estimation (BrainAGE).Methods Twenty-one healthy adult C57BL / 6J male mice,15 months old,were divided into a group with a standard environment and two groups with enriched environments.All the groups underwent magnetic resonance microcopy.Scaled subprofile model was used to analyze the features reflecting the changes of brain cognitive reserve.Results There were significant differences between the mean BrainAGE of the two groups with enriched environments and that of the remained standard environment group,then it's proved that some assumption might be reasonable that brain cognitive reserve could be estimated based on BrainAGE.Optim ized BrainAGE model made explanations for 58.9％ differences during stimulus phase in enriched environment.Conclusion Improved BrainAGE model gains high sensitivity when used to measure the redundancy of brain cognitive reserve.
ABSTRACT
BACKGROUND:Heat Induction Typodont System (HITS) and Double-Slot Lingual Bracket System are patented products of the research group.It is very important to explore a good control of anterior tooth torque on the micro-implant-double-slot lingual bracket system.OBJECTIVE:To provide the experimental basis for force system applied for controlling the anterior tooth torque in lingual orthodontics through Typodont experiment based on the HITS.METHODS:Sixteen Class Ⅱ1 maxillary Typodont models without first premolar were made.Micro-implants were implanted in the lingual region of posterior teeth and labial region of anterior teeth.The direction of the retracting force was adjusted by changing the position of the lingual micro-implant (with a distance of 4,8 mm from the alveolar crest) and the length of the hook (4,8 mm).And lingual retracting force (150,300 g) and labial intruding force (50,100 g) were loaded.The tooth movement by HITS was simulated and the models were scanned before and after force loading.Then the three-dimensional images were reconstructed by Mimics 17.0.Factorial variance analysis was adopted to compare the anterior movement changes under different loading modes.RESULTS AND CONCLUSION:When the length of the hook was 4 mm/8 mm and the lingual micro-implant was 6 mm/10 mm from the alveolar crest,the displacement difference between the incisal edge and the root of the anterior teeth was smaller than other groups.The optimal mechanics was 150 g for the lingual retracting force and 100 g for the labial intruding force.It could provide a satisfactory control to the anterior teeth torque when retracting force and labial intruding force were loaded at the same time during the space closing phase of lingual treatment.This study based on HITS provided a scientific basis for the clinical application of micro-implant-double-slot lingual bracket system in space closing phase.